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The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients. The main questions it aims to answer is:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TBI | Patients with traumatic brain injury. |
| |
| Control | Patients with hydrocephalus. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Type of disease | Other | Different types of pathogen: brain injury by trauma or hydrocephalus due to various diseases. |
|
| Measure | Description | Time Frame |
|---|---|---|
| RNA biomarkers in patients' blood & cerebrospinal fluid assessed by transcriptome bioinformatic analysis | Patients' blood and cerebrospinal fluid will be collected in emergency room and operation room respectively. Then these samples will be immediately prepared to be detected through transcriptome sequencing. The results of transcriptome sequencing will be further analyzed and compared with control group to filter potential RNA biomarkers in blood and cerebrospinal fluid of severe TBI patients. | Immediately after collecting blood & cerebrospinal fluid |
| Protein biomarkers in patients' blood & cerebrospinal fluid assessed by proteomic bioinformatic analysis | Patients' blood and cerebrospinal fluid will be collected in emergency room and operation room respectively. Then these samples will be immediately prepared to be detected through proteomics mass spectrometry. The results of proteomic will be further analyzed and compared with control group to filter potential protein biomarkers in blood and cerebrospinal fluid of severe TBI patients. | Immediately after collecting blood & cerebrospinal fluid |
| Metabolite biomarkers in patients' blood & cerebrospinal fluid assessed by metabolomic bioinformatic analysis | Patients' blood and cerebrospinal fluid will be collected in emergency room and operation room respectively. Then these samples will be immediately prepared to be detected through metabolomic mass spectrometry. The results of metabolomic will be further analyzed and compared with control group to filter potential metabolite biomarkers in blood and cerebrospinal fluid of severe TBI patients. | Immediately after collecting blood & cerebrospinal fluid |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with severe traumatic brain injury or hydrocephalus.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhenghui He | Contact | +8613585916217 | hezhenghui8@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brain Injury Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University | Recruiting | Shanghai | Shanghai Municipality | China |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |