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The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TBI | Patients with traumatic brain injury. |
| |
| ICH | Patients with hypertensive intracranial hemorrhage. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Type of disease | Other | Different types of pathogen: brain injury by trauma or intracranial hemorrhage due to hypertension. |
|
| Measure | Description | Time Frame |
|---|---|---|
| RNA biomarkers in TBI or ICH patients' lesion tissues assessed by transcriptome bioinformatic analysis | Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through transcriptome sequencing. The results of transcriptome sequencing will be further analyzed by bioinformatic analysis to reveal different RNA expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers. | Immediately after collecting tissues |
| Protein biomarkers in TBI or ICH patients' lesion tissues assessed by proteomic bioinformatic analysis | Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through proteomics mass spectrometry. The results of proteomic will be further analyzed by bioinformatic analysis to reveal different protein expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers. | Immediately after collecting tissues |
| Metabolite biomarkers in TBI or ICH patients' lesion tissues assessed by metabolomic bioinformatic analysis | Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through metabolomic mass spectrometry. The results of metabolomic will be further analyzed by bioinformatic analysis to reveal different metabolite expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers. | Immediately after collecting tissues |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with severe traumatic brain injury or hypertensive intracranial hemorrhage.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhenghui He, MD | Contact | +8613585916217 | hezhenghui8@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brain Injury Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University | Recruiting | Shanghai | Shanghai Municipality | China |
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| ID | Term |
|---|---|
| D020299 | Intracranial Hemorrhage, Hypertensive |
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001930 | Brain Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |