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| ID | Type | Description | Link |
|---|---|---|---|
| 5T32AI052073-17 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | NIH |
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Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index case to susceptible contacts within the home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | No intervention will be administered in this arm. Investigators will give families a CO2 monitor to measure average CO2 levels in the home. Investigators will provide a link to the basic CDC isolation guidelines which would be part of standard of care. Investigators will test family members at day 0-1 for baseline testing; and again on day 7 for assessing secondary transmission among susceptible contacts. | |
| Intervention | Experimental | Families are provided with one filtration fan unit per room in their home (and one for the index case; if the family lives in a studio, they would receive 2 units). Investigators will advise families on ventilation improvements in their home. Investigators will provide an instructional pamphlet that describes how the fans work and the importance of ventilation. Investigators will follow-up on day 3-4 to check in and run through a checklist to ensure the fans are working and ventilation improvements are being attempted. Investigators will give families a CO2 monitor to measure average CO2 levels in the home. Investigators will test family members at day 0-1 for baseline testing; and again on day 7 for assessing secondary transmission among susceptible contacts. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Filtration Fan | Device | Investigators are using box fans with attached MERV16 filters, a design that has been tested and published in the scientific literature. |
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| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Covid19 | Investigators will measure the incidence of Covid19 in susceptible contacts on day 7. | 7th day since enrollment in the trial |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of new upper respiratory symptoms | Investigators will measure reported new upper respiratory symptoms in susceptible contacts. | 7th day since enrollment in the trial |
| Average CO2 levels |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yvonne Maldonado, MD | Stanford University | Study Director |
| Abraar Karan, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| San Mateo Medical Center | San Mateo | California | 94403 | United States | ||
| Stanford University Medical Center |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Safe-home pamphlet | Behavioral | The pamphlet has information on how the filtration fans work through visual images; and images of ventilation improvements in the home through opening windows. |
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| Mid-week phone call | Behavioral | On day 3-4 of the study, the study coordinator assigned to the house will call and check in regarding the filtration fan usage and remind families about the importance of filtration and ventilation. |
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Investigators will measure 7 day average CO2 levels in the home (measured in parts per million)
| 7 days |
| Stanford |
| California |
| 94305 |
| United States |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |