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The goal of this clinical trial is to examine the regional protein turnover in tendon tissue from patients with chronic patellar tendinopathy and comparing this to healthy controls. Further we will examine the effect of resistance training on protein turnover in healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic tendinopathy patients | Experimental |
| |
| Healthy controls | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progressive resistance training | Other | Only the control group: 3 exercise bouts within the study period. Comparison between exercised and non-exercised leg. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Protein turnover in tendon tissue from patients with chronic tendinopathy compared to healthy controls | Fractional synthesis rate (FSR) measured in % pr. day in the trypsin-soluble and trypsin-insoluble fraction | 8 days |
| Measure | Description | Time Frame |
|---|---|---|
| Tracer incorporation in isolated fractions of the tendon | 15N hydroxyproline enrichment measured in Mole percent Excess in the trypsin-soluble and trypsin-insoluble fraction | 8 days |
| Tracer incorporation in isolated fractions of the tendon |
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Inclusion Criteria:
Inclusion Criteria for the chronic tendinopathy group:
Exclusion Criteria for all participants:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Kjær, Professor | Institute of Sports Medicine, Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Sports Medicine Copenhagen | Copenhagen | Capital Region | 2400 | Denmark |
Data will be shared with other researchers upon request.
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| ID | Term |
|---|---|
| D000092462 | Patella Fracture |
| D052256 | Tendinopathy |
| ID | Term |
|---|---|
| D000092443 | Knee Fractures |
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
| D009135 | Muscular Diseases |
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| Cross-sectional comparison between healthy and tendinopathic group | Other | Comparison of primary and secondary outcomes. |
|
15N proline enrichment measured in Mole percent Excess in the trypsin-soluble and trypsin-insoluble fraction
| 8 days |
| Anterior-posterior dimensions of patella tendon | Measured in millimeter | 8 days |
| Doppler flow in patella tendon | Classified in grading system from 0-3. | 8 days |
| Subjective pain in patella tendon | Questionnaire | 8 days |
| Subjective measure of physical activity and function | Questionnaire | 1 day |
| Single-leg decline squat test | Subjective pain on a scale from 0-10 | 1 day |
| One leg knee extension strength test | Only control-group. | 8 days |
| Leg press strength test | Only control-group. | 8 days |
| D009140 |
| Musculoskeletal Diseases |
| D013708 | Tendon Injuries |