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To evaluate the relative efficacy of an online intervention based on the Trans-theoretical Model delivered by a fully-automated Chatbot with natural language processing functions versus a control in promoting pneumococcal vaccination uptake among Hong Kong people aged ≥65 years. A total of 374 participants will be randomized evenly to either the intervention group or the control group. Participants in the intervention group will receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3. Participants in the control group will receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3. All participants will be followed up 6 and 12 months after completion of the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Participants receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3. |
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| Control | Active Comparator | Participants receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chatbot-delivered interventions tailored to stage of changes | Behavioral | Participants receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3. |
| Measure | Description | Time Frame |
|---|---|---|
| Pneumococcal vaccination uptake | Self-reported uptake of pneumococcal vaccination within the 12-month follow-up period | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zixin Wang, PhD | Contact | +852 22528740 | wangzx@cuhk.edu.hk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre for Health Behaviours Research, the Chinese University of Hong Kong | Recruiting | Hong Kong | 666888 | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41060654 | Derived | Wang Z, Chen S, Poon J, Han SC, Ye D, Yu FY, Fang Y, Ni Z, Wong MCS, Mo PKH. A Hybrid Chatbot to Promote Pneumococcal Vaccination Among Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2025 Oct 1;8(10):e2535813. doi: 10.1001/jamanetworkopen.2025.35813. |
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| ID | Term |
|---|---|
| D000072758 | Vaccination Refusal |
| ID | Term |
|---|---|
| D016312 | Treatment Refusal |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| Chatbot-delivered standard interventions | Behavioral | Participants receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3. |
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