Genomics and Prognosis in GI Cancers

ClinicalTrials.gov ID

NCT05767697

Lead Sponsor

National Health Research Institutes, TaiwanOTHER

Overall Status

Unknown status

Study Type

Observational

Enrollment

1,000Estimated

Last Update Posted

Mar 26, 2024Actual

Start Date

Apr 15, 2020Actual

Primary Completion Date

Dec 31, 2024Estimated

Completion Date

Dec 31, 2025Estimated

Official Title

Explore the Correlation of Genomics and Prognosis in Alimentary Tract Cancers

Brief Summary

This study aims to collect biospecimens and explore the correlation of genomics and prognosis in alimentary tract cancers.

Detailed Description

In this study, the investigators will collect clinical specimens of alimentary tract cancers and perform DNA and RNA analysis to identify genetic alterations for the development of a comprehensive somatic mutation databases and investigate their potential correlation with clinical, radiological and pathological variables. The genomics study included but not limited to target gene panel sequencing, whole exome sequencing, whole genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.

• GI Cancer
• Liver Cancer

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No data available

Eligibility Criteria

Inclusion Criteria:

• Able to sign the informed consent
• Age >= 20
• Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer
• Agree to provide tumor/normal tissue including but not limited to surgical specimen, biopsy, cytology specimen, bile, urine or stool
• Agree to receive blood sampling 20ml at first time and 10ml during each follow-up (total sampling amount no more than 30ml per month)

Exclusion Criteria:

• Cannot cooperate with blood sampling

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

National Health Research Institutes, TaiwanOTHER

Collaborators

National Cheng-Kung University HospitalOTHER

yysu@nhri.edu.tw+8867-7000123 ext. 65181

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