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Early detection of neonates with higher risk of death is quite important for paying more attention to these cases, timely referral to tertiary neonatal intensive care unit (NICU), and provision of meticulous critical care, which ultimately may improve outcomes. Several scoring systems have recently been developed for assessment of the intensity of illness and prognosticate the risk of not only neonatal mortality but also short- and long-term morbidities. The accuracy of these scoring systems has been investigated in several NICUs from different countries, such as USA, UK, Canada, Brazil, India, and Iran. Previous Egyptian studies have investigated the accuracy of Clinical Risk Index for Babies II (CRIB II), Score for Neonatal Acute Physiology II (SNAP-II) and its Perinatal Extension II (SNAPPE-II). However, the accuracy of Sensorium, temperature, oxygenation, perfusion, skin color, and blood sugar (STOPS), Modified Sick neonatal Score (MSNS), and neonatal sequential organ failure assessment (nSOFA) has not been investigated in Egyptian NICUs. Therefore, more studies are required to investigate the utility and accuracy of neonatal risk assessment scores in Egyptian NICUs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study participants | Neonates admitted to NICU and fulfilling eligibility criteria |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CRIB II | Other | Calculate Clinical Risk Index for Babies II score |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Survival at discharge | Proportion of neonates discharged alive from NICU | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | Length of stay in NICU | One year |
| Need for CPAP | Proportion of neonates connected to continuous positive airway pressure |
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Inclusion Criteria:
Exclusion Criteria:
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Neonates admitted to NICUs at Sohag University Hospitals during the study duration
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rehab Z Abdelftah, MD | Contact | 01062757889 | rehabzain@med.sohag.edu.eg | |
| Elsayed Abdelkreem, MD, PhD | Contact | 00201114232126 | d.elsayedmohammed@med.sohag.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Montaser M Mohamed, MD, PhD | Sohag University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neonatal Intensive Care Units at Sohag University Hospitals | Recruiting | Sohag | 82524 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28372507 | Background | Garg B, Sharma D, Farahbakhsh N. Assessment of sickness severity of illness in neonates: review of various neonatal illness scoring systems. J Matern Fetal Neonatal Med. 2018 May;31(10):1373-1380. doi: 10.1080/14767058.2017.1315665. Epub 2017 Apr 20. | |
| 35524143 | Background | Vardhelli V, Murki S, Tandur B, Saha B, Oleti TP, Deshabhotla S, Mohammed YA, Seth S, Siramshetty S, Kallem VR. Comparison of CRIB-II with SNAPPE-II for predicting survival and morbidities before hospital discharge in neonates with gestation </= 32 weeks: a prospective multicentric observational study. Eur J Pediatr. 2022 Jul;181(7):2831-2838. doi: 10.1007/s00431-022-04463-2. Epub 2022 May 6. |
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Unidentified individual participant data will be available from the principal investigator upon a reasonable request
After publication and for three years
Available from the principal investigator upon a reasonable request
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 5, 2024 | |
| Reset | Nov 22, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 5, 2024 | Nov 22, 2024 |
| ID | Term |
|---|---|
| D066087 | Perinatal Death |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003643 | Death |
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| SNAP-II |
| Other |
Calculate Score for Neonatal Acute Physiology II |
|
| SNAPPE-II | Other | Calculate Score for Neonatal Acute Physiology Perinatal Extension II |
|
| STOPS | Other | Calculate Sensorium, temperature, oxygenation, perfusion, skin color, and blood sugar score |
|
| MSNS | Other | Calculate Modified Sick neonatal Score |
|
| nSOFA | Other | Calculate neonatal sequential organ failure assessment |
|
| One year |
| Need for invasive ventilation | Proportion of neonates requiring invasive ventilation | One year |
| 12781540 | Background | Parry G, Tucker J, Tarnow-Mordi W; UK Neonatal Staffing Study Collaborative Group. CRIB II: an update of the clinical risk index for babies score. Lancet. 2003 May 24;361(9371):1789-91. doi: 10.1016/S0140-6736(03)13397-1. |
| 11148519 | Background | Richardson DK, Corcoran JD, Escobar GJ, Lee SK. SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores. J Pediatr. 2001 Jan;138(1):92-100. doi: 10.1067/mpd.2001.109608. |
| 36136230 | Background | Vardhelli V, Seth S, Mohammed YA, Murki S, Tandur B, Saha B, Oleti TP, Deshabhotla S, Siramshetty S, Kallem VR. Comparison of STOPS and SNAPPE-II in Predicting Neonatal Survival at Hospital Discharge: A Prospective, Multicentric, Observational Study. Indian J Pediatr. 2023 Aug;90(8):781-786. doi: 10.1007/s12098-022-04330-w. Epub 2022 Sep 22. |
| 31210987 | Background | Mansoor KP, Ravikiran SR, Kulkarni V, Baliga K, Rao S, Bhat KG, Baliga BS, Kamath N. Modified Sick Neonatal Score (MSNS): A Novel Neonatal Disease Severity Scoring System for Resource-Limited Settings. Crit Care Res Pract. 2019 May 9;2019:9059073. doi: 10.1155/2019/9059073. eCollection 2019. |
| 31394566 | Background | Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020 Jul;88(1):85-90. doi: 10.1038/s41390-019-0517-2. Epub 2019 Aug 8. |
| 26266178 | Background | Ezz-Eldin ZM, Hamid TA, Youssef MR, Nabil Hel-D. Clinical Risk Index for Babies (CRIB II) Scoring System in Prediction of Mortality in Premature Babies. J Clin Diagn Res. 2015 Jun;9(6):SC08-11. doi: 10.7860/JCDR/2015/12248.6012. Epub 2015 Jun 1. |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |