Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis

Clinical Study Evaluating the Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis

Evaluating the effect of the flavonoids combination (diosmin and hesperidin) as adjuvant therapy on patients with rheumatoid arthritis

Evaluation of the anti inflammatory and antioxidant effects of the flavonoids combination (diosmin and hesperidin) as adjuvant therapy on patients with rheumatoid arthritis.

Clinical and functional assessment of disease activity.

Evaluation of hepatoprotective effect against methotrexate induced liver adverse events.

Inclusion Criteria:

• Patients with mild to moderate disease activity.
• Patient age must be more than 18 years.

Exclusion Criteria:

• Pregnant and lactating females.
• Patients with liver, renal impairment or any other inflammatory diseases.
• Patients on TNF-α (tumor necrosis factor- α) or IL-1β (interleukin-1β) antagonists.