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The primary aim of this pilot randomized controlled trial is to determine feasibility of the proposed pulmonary rehabilitation intervention.
In this pilot randomized controlled trial, our primary aim is to determine feasibility of the proposed intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High flow oxygen | Experimental | High flow nasal oxygen |
|
| Usual care | Active Comparator | room air or normal flow oxygen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High flow oxygen | Device | Use of HFO |
| |
| Usual care |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in 1-minute sit to stand test | maximum number of sit to stand cycles in 1 minute | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in 30-second sit to stand test | maximum number of sit to stand cycles in 30 seconds | 1 month, 3 month |
| Changes in respiratory symptoms | Modified Medical Research Council Dyspnea Scale. The scale ranges from 0 to 4 with a higher score indicating increasing breathlessness |
| Measure | Description | Time Frame |
|---|---|---|
| Qualitative interview | Qualitative interviews will also be conducted to obtain patient perspectives of the interventions in the study | Upon completion of study, or when patients end participation in the study |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yingjuan Mok, MBBS | Contact | 69366603 | mok.yingjuan@singhealth.com.sg |
| Name | Affiliation | Role |
|---|---|---|
| Yingjuan Mok | Changi General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changi General Hospital | Recruiting | Singapore | 529889 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42397015 | Derived | Mok Y, Foong JW, Wong HS, Shih-Yen EC, Hassan N, Klainin-Yobas P, Soh LC, Soh A, Tan SH, Koh XH, Tan PC, Wong KKH. High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial. Respirology. 2026 Jul 3. doi: 10.1002/resp.70277. Online ahead of print. |
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| Other |
Room air or normal flow oxygen |
|
| 1 month, 3 months |
| Changes in mood | Hospital Anxiety Depression Scale. The scale ranges from 0 to 21, A total subscale score of >8 points indicates considerable symptoms of anxiety or depression. | 1 month, 3 month |
| changes in quality of life | EQ-5D-5L | 1 month, 3 month |
| Changes in lung function | Forced expiratory volume in 1 sec | 1 month, 3 month |
| Changes in lung function | forced vital capacity | 1 month, 3 month |
| Proportion of patients who still have exertional hypoxemia | Comparing the proportion of patients who still have exertional hypoxemia | 1 month, 3 month |
| Adherence rates | Comparing the adherence rates between the 2 study arms | 3 week |
| Changes in 1-minute sit to stand test | maximum number of sit to stand cycles in 1 minute | 3 month |