The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.

Inclusion Criteria:

• American Society of anaesthesiologists physical status I to III.
• Open abdominal hysterectomy operations

Exclusion Criteria:

• History of gastrointestinal bleeding.
• History of intracranial haemorrhage.
• Pregnancy and lactation.
• Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs.
• Asthmatic, hepatic,renal or heart failure.
• Abnormal platelet count.