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This study aims to compare the effectiveness and safety of ultrasound-guided rectus sheath block versus intrathecal morphine for postoperative analgesia in patients undergoing open total abdominal hysterectomy.
Effective postoperative analgesia is crucial for enhancing recovery and patient satisfaction following major surgical procedures, such as total abdominal hysterectomy (TAH).
Rectus sheath block (RSB), an ultrasound-guided regional anesthesia technique, involves the injection of local anesthetic into the rectus sheath, providing analgesia to the anterior abdominal wall. RSB is used to block the sensory nerves of the anterior abdominal wall and thereby contributing to pain relief after lower abdominal surgeries.
Intrathecal morphine (ITM) provides a highly effective method of analgesia by delivering the medication directly into the cerebrospinal fluid (CSF).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rectus sheath block group | Experimental | Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia. |
|
| Intrathecal morphine group | Experimental | Patients will receive 150 µg intrathecal morphine after induction of general anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rectus sheath block | Drug | Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total morphine consumption | Morphine will be administered if the visual analog scale (VAS) score is ≥ 4. | 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Time to the first request for the rescue analgesia | Time to the first request for the rescue analgesia (time from the end of surgery till first dose of morphine administrated) | 24 hours postoperatively |
| Degree of pain |
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Inclusion Criteria:
Exclusion Criteria:
Women undergoing open total abdominal hysterectomy
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sarah A Afifi, MD | Contact | 0501035864 | Sarah606060@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Recruiting | Cairo | 11591 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
After the end of study for one year.
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| Intrathecal morphine | Drug | Patients will receive 150 µg intrathecal morphine after induction of general anesthesia. |
|
Each patient will be instructed about postoperative pain assessment with the Visual Analogue Scale (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable"). VAS will be assessed after surgery over 24 hour using VAS scale at (post-anesthesia care unit, 2, 4, 6, 12, 18, and 24 h).
| 24 hours postoperatively |
| Degree of sedation | Sedation will be assessed using Modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S): (5 Alert: Responds readily to name spoken in normal tone, 4: Lethargic response to name spoken in normal tone, 3: Responds only after name is called loudly and/or repeatedly, 2: Responds only after mild prodding or shaking ,1: Responds only after painful trapezius squeeze,0: Does not respond to painful trapezius squeeze). | Intraoperatively |
| Degree of patient satisfaction | The degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied). | 24 hours postoperatively |
| Time of hospital discharge | Time of hospital discharge will be recorded from admission till the discharge from hospital. | 28 days postoperatively |
| Incidence of adverse events | Incidence of adverse events such as hematoma, nerve damage or neuropathy, bradycardia, hypotension, nausea, vomiting, pruritis, or any other complication will be recorded. | 24 hours postoperatively |