Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury

Regulation of Protein Turnover in Connective Tissue From Muscle and Tendon Following Muscle Tissue Injury

The study is a 2-week human study where 40 patients who are scheduled to undergo reconstructive knee surgery are randomized to administration of GH or placebo following or without neuromuscular electrical stimulation of hamstring muscles.The overall aim is to determine, the role of muscle connective tissue protein synthesis in muscle injury and repair.

Inclusion Criteria:

• Healthy men and women scheduled to undergo reconstructive knee surgery
• BMI 18-35

Exclusion Criteria:

• Former or current use of growth hormone or anabolic steroids
• Use of corticosteroids in the past 3 months
• Use of any medication known to affect muscle or tendon turnover
• Former participation in a study using deuterated water
• Chronic diseases