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| Name | Class |
|---|---|
| Jinnah Postgraduate Medical Centre | OTHER_GOV |
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The goal of this clinical trial is to compare the pain relief and healing effect of A-PRF and Bone-wax in patients having mandibular tooth-extractions. The main question[s] it aims to answer are:
In the perspective of improvement in pain and healing;
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A-PRF | Experimental | Advance Platelet-Rich Fibrin |
|
| Bone-wax | Active Comparator |
| |
| Conventional Dental Extraction protocol | No Intervention | Control Group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| A-PRF | Biological | 0.5 to 1g of Advance Platelet-Rich Fibrin (A-PRF) clot for each dental socket. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain Relief on VAS | Patients receiving any of the intervention will be evaluated at just before, 3rd, 7th and 21st day of dental extraction on Visual Analogue Scale (VAS). | 21 days |
| Extraction socket healing | Patients receiving any of the intervention will be evaluated at 3rd, 7th and 21st day of dental extraction on Healing index by Landry et al. | 21 days |
| Measure | Description | Time Frame |
|---|---|---|
| Hemostasis | The post-operative bleeding will be evaluated 30 minutes after the placement of the last suture as:
|
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jinnah Postgraduate Medical Centre | Recruiting | Karachi | Sindh | 75510 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11010778 | Background | Ruta DA, Bissias E, Ogston S, Ogden GR. Assessing health outcomes after extraction of third molars: the postoperative symptom severity (PoSSe) scale. Br J Oral Maxillofac Surg. 2000 Oct;38(5):480-7. doi: 10.1054/bjom.2000.0339. | |
| Background | Landry RG, Turnbell RS, Howley T (1988) Effectiveness of benzydamine HCL in treatment of periodontal post-surgical patients. Res Clin Forums 10:105-118. | ||
| 26028867 |
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As per institutional data privacy policy we are bound of not sharing patient data with other researchers
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C055480 | bone wax |
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| Bone-wax | Combination Product | 0.5 to 1g of Bone-wax for each dental socket |
|
|
| 30 minutes |
| Background |
| Yelamali T, Saikrishna D. Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study. J Maxillofac Oral Surg. 2015 Jun;14(2):410-6. doi: 10.1007/s12663-014-0638-4. Epub 2014 Jun 28. |