This protocol will involve collection of blood samples from patients with a diagnosis of pancreatic adenocarcinoma for evaluation of circulating biomarkers.

Inclusion Criteria:

• The subject must have a known or presumed diagnosis of pancreatic adenocarcinoma
• The subject must be a patient of the University of Pennsylvania
• The subject must be able to provide informed consent
• The subject must be 18 years of age or older

Exclusion Criteria:

. Subjects who have any clinically significant psychiatric, social, or medical condition that, in the opinion of the investigator, could increase the patient's risk, interfere with protocol adherence, or affect the patient's ability to give informed consent are ineligible to participate in the study.

known or suspected diagnosis of pancreatic adenocarcinoma