The purpose of this study is to collect blood samples to detect potential markers of pancreatic cancer in the blood and link these findings to medical and health information. Information from this study may help to provide insight into the detection of pancreas cancer in the blood before it can be found by other methods or provide a method of monitoring the status of pancreatic cancer throughout a treatment course. Another purpose of this study is to collect blood to create a biobank.

Inclusion Criteria:

1. The subject must be a patient at the Hospital of the University of Pennsylvania

   • The subject must be under evaluation and/or treatment for a pancreatic disease
   • The subject must be under evaluation and/or treatment for a non-pancreatic disease. For example, patients undergoing routine colonoscopy within the clinical practice will be asked to consent to provide control samples.

2. The subject must be able to provide informed consent or have an acceptable surrogate capable of giving consent on the subject's behalf

3. The subject must be 18 years of age or older

Exclusion Criteria:

1. The subject or acceptable surrogate does not provide informed consent
2. Subject is a prisoner
3. Subject is under 18 years of age

subjects with pancreatic diseases