Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 infection group | Infertile women attending for frozen embryo transfer with a recent past COVID-19 infection |
| |
| Control group | Infertile women attending for frozen embryo transfer without a recent past COVID-19 infection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| frozen embryo transfer | Other | transfer one or two embryos in frozen embryo transfer cycles |
|
| Measure | Description | Time Frame |
|---|---|---|
| live birth rate | live birth rate of the frozen embryo transfer cycle (>22 weeks of gestation) | a live birth after 22 weeks gestation |
| Measure | Description | Time Frame |
|---|---|---|
| serum hCG level | serum hCG level | a blood pregnancy test is performed 14 days after the embryo transfer |
| clinical pregnancy | presence of intrauterine gestational sac on ultrasound |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Infertile women for frozen embryo transfer will be recruited for study after explanation and counseling if they fulfil the inclusion criteria and do not have the exclusion criteria.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Xiaoxi Sun, PhD | Shanghai JiAi Genetics & IVF Institute | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ShangHai JIAI Genetics&IVF Institute | Shanghai | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32246845 | Background | Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW, Hennig BP, Kreuter M, Conrad C, Eils R. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J. 2020 May 18;39(10):e105114. doi: 10.15252/embj.20105114. Epub 2020 Apr 14. | |
| 32170560 |
Not provided
Not provided
Individual participant data that underlie the results after deidentification (text, tables, figures, and appendices) and study protocol will be shared. Data will be available when beginning 3 months and ending 5 years following article publication. To achieve aims in the approved proposal, researchers who provide a methodologically sound proposal will be shared with.Data will be made available by the following way. Proposals should be directed to lihe198900@163.com. And data are available for 5 years at a third party website (link to be included after the article publication
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Serum sample is obtained on the day of progesterone supplementation day or luteinizing hormone surge day, and saved for further COVID-19 antibody test.
| presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy |
| ongoing pregnancy | viable pregnancy beyond gestation 12 weeks | viable pregnancy beyond gestation 12 weeks |
| biochemical pregnancy | positive blood pregnancy test not followed by clinical pregnancy | positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation |
| implantation rate | number of gestational sacs per embryo transferred | number of gestational sacs per embryo transferred during 4 weeks of pregnancy |
| multiple pregnancy | more than one intrauterine sacs on scanning | multiple pregnancy beyond gestation 12 weeks |
| ectopic pregnancy | pregnancy outside the uterine cavity | ectopic pregnancy during 12 weeks gestation |
| miscarriage | the loss of a pregnancy before 22 weeks gestation | the loss of a pregnancy before 22 weeks gestation |
| birth weight | birth weight of the baby delivered | a live birth after 22 weeks gestation |
| serum COVID-19 antibody level | serum COVID-19 antibody level immunoglobulin G and immunoglobulin M | 7 days before embryo transfer |
| Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 Apr;14(2):185-192. doi: 10.1007/s11684-020-0754-0. Epub 2020 Mar 12. |
| 19164480 | Background | Vaz-Silva J, Carneiro MM, Ferreira MC, Pinheiro SV, Silva DA, Silva-Filho AL, Witz CA, Reis AM, Santos RA, Reis FM. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reprod Sci. 2009 Mar;16(3):247-56. doi: 10.1177/1933719108327593. Epub 2009 Jan 22. |
| 32641214 | Background | Henarejos-Castillo I, Sebastian-Leon P, Devesa-Peiro A, Pellicer A, Diaz-Gimeno P. SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. Fertil Steril. 2020 Aug;114(2):223-232. doi: 10.1016/j.fertnstert.2020.06.026. Epub 2020 Jun 17. |
| 35216833 | Background | Aizer A, Noach-Hirsh M, Dratviman-Storobinsky O, Nahum R, Machtinger R, Yung Y, Haas J, Orvieto R. The effect of coronavirus disease 2019 immunity on frozen-thawed embryo transfer cycles outcome. Fertil Steril. 2022 May;117(5):974-979. doi: 10.1016/j.fertnstert.2022.01.009. Epub 2022 Jan 10. |
| 35525900 | Background | Youngster M, Avraham S, Yaakov O, Landau Rabbi M, Gat I, Yerushalmi G, Baum M, Maman E, Hourvitz A, Kedem A. The impact of past COVID-19 infection on pregnancy rates in frozen embryo transfer cycles. J Assist Reprod Genet. 2022 Jul;39(7):1565-1570. doi: 10.1007/s10815-022-02517-w. Epub 2022 May 7. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |