Prognosis of Cerebral Small Vessel Disease

Prognosis of Cerebral Small Vessel Disease - a Prospective Cohort Study (PRO-SVD)

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation.

The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

Inclusion Criteria:

• Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with either ICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
• Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria), clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitive impairment or severe radiological manifestation (CMB≥2)
• Other SVD (i.e. CADASIL or other sporadic or genetic SVD)

Exclusion Criteria:

• Life expectancy of <6 months due to not-SVD related causes (i.e. cancer)
• Patient is unlikely to attend follow-up visits