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The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Small Vessel Disease (CSVD) and in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CSVD, , to find independent imaging markers, and to optimize clinical management.
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| Measure | Description | Time Frame |
|---|---|---|
| Overall outcomes in patients with cerebral small vessel disease. | record the occurrence of stroke and use modified Rankin Scale (mRS) to measure the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. | From date of enrollment until the date of death from any cause, assessed up to 30 years |
| Measure | Description | Time Frame |
|---|---|---|
| the development of the burden of microbleeds in MRI | using MARS scale to evaluate the development of the burden of microbleeds | From date of enrollment until the date of death from any cause, assessed up to 30 years |
| the development of the burden of white matter hypertension in MRI |
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Inclusion Criteria:
Exclusion Criteria:
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Patient who are diagnosed as Cerebral Small Vessel Disease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bin Cai, PhD | Contact | 13338413842 | 86 | caibin929@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology , First Affiliated Hospital Fujian Medical University | Recruiting | Fuzhou | Fujian | 350004 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40067051 | Derived | Hu F, Xie W, Fan M, Wang Y, Xu S, Qiu W, Yang T, Lv H, Huang H, Wu Y, Fu Y, Cai B. Intracerebral Hemorrhage in Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. Eur J Neurol. 2025 Mar;32(3):e70100. doi: 10.1111/ene.70100. |
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| ID | Term |
|---|---|
| D059345 | Cerebral Small Vessel Diseases |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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using Fazakes scale to evaluate the development of the burden of white matter hypertension |
| From date of enrollment until the date of death from any cause, assessed up to 30 years |
| the development of lacunes in MRI | record the number and location of lacunes | From date of enrollment until the date of death from any cause, assessed up to 30 years |
| the development of enlarged perivascular space in MRI | record the number and location of enlarged perivascular space | From date of enrollment until the date of death from any cause, assessed up to 30 years |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |