Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment

Intubation Conditions After Rapid Sequence Induction Using Different Doses of Rocuronium with Ephedrine Pretreatment: a Randomized Controlled Trial

This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.

Inclusion Criteria:

• ASA physical status I or II

Exclusion Criteria:

• Neuromuscular disease: myopathies

• On drugs that interact with the neuromuscular junction or ephedrine

• Cardiovascular disease: hypertension or ischemic heart disease

• Increased risk of pulmonary aspiration:

  • GERD
  • Pregnancy

• Anticipated airway difficulties:

  • Mallampati grade III or IV
  • Obesity (BMI ≥30 kg/m2),

• Hypersensitivity to any of the study drugs