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In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.
Patients are pretreated with Mg, ketamine, or priming dose Roc. Two groups do not receive pretreatment, but are given Roc 0.6 mg/kg or 0.9 mg/kg.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ketamine | Experimental | Patients receive ketamine 0.5 mg/kg 2 min before Roc injection. |
|
| priming | Experimental | Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg. |
|
| Roc 0.9 | No Intervention | Patients receive Roc 0.9 mg/kg as an induction dose. | |
| Control | No Intervention | Patients receive Roc 0.6 mg/kg without any pretreatments of Mg, ketamine, or priming. | |
| Mg | Experimental | Patients receive magnesium sulfate (MgSO4) 50 mg/kg over 10 min before Roc injection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium Sulfate | Drug | Patients receive MgSO4 50 mg/kg for 10 min before injection of Roc 0.6 mg/kg. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intubation score | Patients are tracheally intubated, and intubation scores(poor, good,excellent)are rated. | participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection. |
| Measure | Description | Time Frame |
|---|---|---|
| Roc duration | Time from the start of rocuronium injection until reappearance of two muscle twitches in TOF stimulations is measured, using ToF-Watch sx. | participants will be followed when TOF count reaches two, an expected average of 40 min. |
| Roc onset |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mihyun Kim, doctor | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang hopital | Seongnam-si | Gyeonggi-do | 464-707 | South Korea |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D007649 | Ketamine |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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| Ketamine | Drug | patients receive ketamine 0.5 mg/kg 2 min before Roc injection. |
|
| rocuronium | Drug | Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg. |
|
Time from the start of rocuronium injection until TOF count=0 using TOF-Watch sx. |
| participants will be followed when TOFcount =0 within an expected average of 4 min from the start of rocuronium injection. |
| Hemodynamic variables | Mean arterial pressure (MAP)and heart rate (HR) are measured at baseline, before intubation, and 1, 2, 3, 4, 5 min after intubation. | participants will be followed at baseline, before and for 5 min after the intubation, an expected average of 8 min after the start of anesthetic induction. |
| TOF% at intubation | neumeric value expressed as %, displayed on the monitor of TOF watch-Sx in TOF stimulation (ex. 5% on the display means 95% suppression of T1) | participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection. |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |