Effect of Recombinant Human Bone Morphogenetic Protein-2 With an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study.

Effect of Recombinant Human Bone Morphogenetic Protein-2 With an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study of 6\12\2021 to20\4\2023

Effect of Recombinant Human Bone Morphogenetic Protein-2 with an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study.

The Primary outcome will be measuring the effect of rhBMP- 2/ACS in improving the secondary stability of dental implant by using RFA in comparison to control group.

Secondary outcome association of the effect of other factors (ridge dimension, bone density) on dental implant stability.

Inclusion Criteria:

• Patients have good oral hygiene.
• Systemic healthy individuals ,Age more than18 years.
• Healed edentulous area for at least 6 months after tooth extraction (delayed implant protocol).
• Patients have at least two missing teeth in the jaw (canine to 1st molar area) indicated for the dental implant.

Exclusion Criteria:

• Presence of systemic diseases preventing implantation.
• Previous implantation or augmentation of the same region.
• The need for additional bone augmentation procedures (such as maxillary sinus augmentation)
• Partial or total edentulous ridge associated with a severe knife-edge ridge .
• Acute infection or any pathological lesion a the implant site.
• Allergy to one of the materials to be used during operation.
• Pregnancy.
• Radiation therapy, bisphosphonate drugs , Osteoradionecrosis.