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The goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology.
The main questions it aims to answer are :
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasal swab | Diagnostic Test | We will take nasal swabs from anterior and middle nostril, once a week for each newborn included. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in microbiome diversity | Shannon diversity index | Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn). |
| Change in microbiome abundance | Number of reads for a given taxonomy. | Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn). |
| Virus presence | Molecular detection of respiratory viruses using multiplex PCR. | Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn). |
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of bronchopulmonary dysplasia | assessed by clinical recording on discharge from neonatology | At discharge from neonatology. |
| Change in expression of local innate immunity markers | Mesure of the expression of the interferon-stimulated genes (ISGs), anti-viral genes, and the inflammasome pathway. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CAEN University Hospital | Caen | France |
Individual participant data will be anonymised.
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| ID | Term |
|---|---|
| D003141 | Communicable Diseases |
| D014777 | Virus Diseases |
| ID | Term |
|---|---|
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn). |