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| Name | Class |
|---|---|
| NotCo Brasil Distribuicao e Comercio de Produtos Alimenticios LTDA | UNKNOWN |
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This is a randomized controlled trial aimed to investigate the effects of different supplementary protein sources on muscle adaptations to resistance exercise. Young, healthy, recreationally active participants consuming an omnivorous diet with protein intake within recommended dietary allowance (RDA) (i.e.; 0.8-1.0 g.kg-1. d-1) will be recruited to undergo a 12-wk supervised resistance training program in combination with the intake of three 15-g daily doses (45g. d-1 total) of either a mixed plant- (i.e.; soy and pea protein) or animal-based (i.e.; whey protein) protein in drink form as a supplementary source of protein to their main meals of the day (i.e.; breakfast, lunch, and dinner). Before (PRE) and after (POST) the 12-wk intervention, participants will be assessed for body composition by dual-energy X-ray absorptiometry (DXA), muscle cross-sectional area (ultrasound) and fiber cross-sectional area (muscle biopsy), and maximal isotonic strength (1RM). Training consists of a resistance training (RT) program individually supervised by a researcher blinded to treatment in a laboratorial setting. Assessments will also be conducted in a blinded fashion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| animal protein | Active Comparator | Whey protein will be used as the active comparator for animal protein arm |
|
| plant protein | Experimental | A combination of pea and soy protein will be used as the experimental arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Animal protein | Dietary Supplement | Patients allocated to this arm will be submitted a supervised resistance training program in combination with the intake of three 15-g daily doses (45g. d- 1 total) animal-based protein (i.e.; whey protein) in drink form as a supplementary source of protein in their main meals of the day. |
| Measure | Description | Time Frame |
|---|---|---|
| vastus lateralis muscle cross sectional area | the investigators used ultrasound measures of the vastus lateralis cross sectional area as the primary outcome | Ultrasound images will be obtained both at baseline (before the comencement of the study) and immediately after the 12-week intervention period |
| Measure | Description | Time Frame |
|---|---|---|
| lean mass | total body and lower limb lean mass assessed by DXA | DXA scans will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period |
| fiber cross sectional area |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hamilton Roschel, PhD | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | São Paulo | 05508-030 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41059835 | Derived | Santini MH, Erwig Leitao A, Mazzolani BC, Smaira FI, de Souza MSC, Santamaria A, Gualano B, Roschel H. Similar effects between animal-based and plant-based protein blend as complementary dietary protein on muscle adaptations to resistance training: findings from a randomized clinical trial. J Int Soc Sports Nutr. 2025 Dec;22(1):2568047. doi: 10.1080/15502783.2025.2568047. Epub 2025 Oct 8. |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D010940 | Plant Proteins |
| ID | Term |
|---|---|
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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|
| Plant Protein | Dietary Supplement | Patients allocated to this arm will be submitted a supervised resistance training program in combination with the intake of three 15-g daily doses (45g. d- 1 total) mixed plant protein (i.e.; soy and pea) in drink form as a supplementary source of protein in their main meals of the day. |
|
vastus lateralis fiber cross sectional area from muscle biopsy samples
| Fiber cross sectional areas will be measured both at baseline (before the comencement of the study) and immediately after the 12-week intervention period |
| maximal isotonic strength | lower-limb maximal isotonic strength will be assessed in the leg-press exercise by means of the one-repetition-maximum test (1-RM test) | 1-RM tests will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period |