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Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after treatment in comparison to healthy controls. This, in turn, would provide insights regarding the role of TCMs in vitiligo and the role of early treatment in halting disease progression and autoimmune memory formation that accounts for high recurrence rate of vitiligo
Assessing the level of circulating TCMs (CD8+ CD3+ CCR7+ CD45RO+ cells) in early localized vitiligo cases where samples will be processed and stained for CD8, CD3, CCR7, . CCR7, CD45R. Multi-parametric flow cytometry will be used to quantify CD3+ve, CD8+ve, CCR7+ve, CD45RO+ve TCM cells percentage, which will be expressed as a percentage from the total lymphocyte gate. This will be done prior to treatment and after treatment and will be compared to healthy controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early localized vitiligo on topical treatment | Active Comparator | Cases will only receive topical steroids/ calcineurin inhibitors and targeted phototherapy |
|
| Early localized vitiligo on topical and systemic treatment | Active Comparator | Cases will receive oral mini-pulse steroids, topical steroids/ calcineurin inhibitors and targeted phototherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral mini pulse | Drug | 5mg / week oral dexamethasone |
|
| Measure | Description | Time Frame |
|---|---|---|
| comparing level of circulating central memory T cells (TCM) in early localized vitiligo cases to healthy controls | comparing TCM levels in early localized vitiligo cases prior to and after treatment to healthy controls | 6 months |
| percent change in the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment | assessing the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment and calculating percent change in their levels | 6 months |
| comparing percent change in the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment in those receiving systemic treatment to those receiving only topical treatment | assessing the level of circulating central memory T cells (TCM) in early localized vitiligo cases after treatment and calculating percent change in their levels in those receiving systemic treatment to those receiving only topical treatment | 6 months |
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Inclusion Criteria:
- Subjects with vitiligo localized to one anatomical area, of ≤ 6 months' duration
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Samia Esmat, MD | Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university hospitals, dermatology outpatient clinic | Cairo | Egypt |
Participants' data that underlie reported results will be shared upon request, after deidentification
Beginning 3 months and ending 12 months after article publication
Controlled Access:
Researchers who provide a methodologically sound proposal will be allowed to access data to achieve aims in the approved proposal
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| ID | Term |
|---|---|
| D014820 | Vitiligo |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C585595 | Floderm topical cream |
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| Topical cream | Drug | topical fluticasone cream for body lesions and topical tacrolimus for face lesions |
|
| targeted phototherapy | Device | twice weekly targeted excimer light sessions |
|