3D Ultrasound for the Imaging of Lymph Nodes in Patients With Breast Cancer

3D Ultrasound Imaging of the Axillary Lymph Nodes

This early phase I studies how well a new 3D ultrasound (3D-US) imaging technology works in evaluating lymph nodes in patients with breast cancer. Ultrasound uses high-frequency sound waves to generate images of the body.

PRIMARY OBJECTIVES:

I. Conducting a pilot study to optimize the in vivo performance of the newly developed three-dimensional (3D)-ultrasound (US) technology.

II. Evaluate the performance of the new 3D-US technique in differentiating benign from malignant lymph nodes in patients.

III. Compare the performance of the new 3D-US method with conventional two-dimensional (2D)-US for localizing the clipped lymph nodes.

OUTLINE:

Patients undergo 3D-US on study. Patients who have a lymph node clip placed and undergoing neoadjuvant chemotherapy undergo imaging of the clipped node before surgery.

Inclusion Criteria:

• Patients with lymph node biopsy or lymph node clip placement as per routine clinical care.
• Age of 18 or older.

Exclusion Criteria:

• Vulnerable subjects such as prisoners and adults lacking capacity to consent.