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Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3/7 RT method | Experimental | perform interval- type endurance exercise at high intensity and resistance training with the 3/7 method |
|
| 3X9 RT method | Active Comparator | perform interval- type endurance exercise at high intensity and resistance training with the 3X9 method |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3/7 Resistance Training Method | Other | 3/7 Resistance Training Method |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Peak VO2 after 3 months | Change in Peak oxygen consumption (VO2) after three 3 months intervention | Baseline and 3 months |
| Change in strength knee extensor after 3 months | Change in strength knee extensor (60°/sec) after three months intervention | Baseline and 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in VE/VCO2 slope after 3 months | Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention | Baseline and 3 months |
| Change in submaximal exercise capacity after 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexis Gillet | Université Libre de Bruxelles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme Hospital | Brussels | 1070 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30756168 | Background | Stragier S, Baudry S, Carpentier A, Duchateau J. Efficacy of a new strength training design: the 3/7 method. Eur J Appl Physiol. 2019 May;119(5):1093-1104. doi: 10.1007/s00421-019-04099-5. Epub 2019 Feb 12. | |
| 33044332 | Background | Duchateau J, Stragier S, Baudry S, Carpentier A. Strength Training: In Search of Optimal Strategies to Maximize Neuromuscular Performance. Exerc Sport Sci Rev. 2021 Jan;49(1):2-14. doi: 10.1249/JES.0000000000000234. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
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| 3X9 Resistance Training Method |
| Other |
3X9 Resistance Training Method |
|
Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1)
| Baseline and 3 months |
| Change in workload maximal after 3 months | Change in workload max at baseline and 3 months intervention | Baseline and 3 months |
| Change in Body fat after 3 months | Change in Body fat at baseline and 3 months intervention | Baseline and 3 months |
| Change in lean mass after 3 months | Change in lean mass at baseline and 3 months intervention | Baseline and 3 months |
| Change in leg lean mass after 3 months | Change in leg lean mass at baseline and 3 months intervention | Baseline and 3 months |
| Change in bone mass after 3 months | Change in bone mass at baseline and 3 months intervention | Baseline and 3 months |
| Change in Visceral adipose tissue after 3 months | Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention | Baseline and 3 months |
| Change in hand grip force after 3 months | Change in hand grip force on non dominant hand at baseline and 3 months intervention | Baseline and 3 months |
| Change in ventilation metaboreflex function after 3 months | Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.) | Baseline and 3 months |
| Change in diastolic blood pressure metaboreflex function after 3 months | Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention | Baseline and 3 months |
| Change in heart rate at rest after 3 months | Change in heart rate at baseline and 3 months intervention | Baseline and 3 months |
| Change in resting heart rate variability at rest after 3 months | Change in resting heart rate variability at baseline and 3 months intervention | Baseline and 3 months |
| Change 30 s sit-to-stand after 3 months | Change 30 s sit-to-stand at baseline and 3 months intervention | Baseline and 3 months |
| Change in isometric strength knee extensor after 3 months | Change in strength knee extensor (isometric) at baseline and 3 months intervention | Baseline and 3 months |
| Change in 120°/sec strength knee extensor after 3 months | Change in strength knee extensor (120°/sec) at baseline and 3 months intervention | Baseline and 3 months |
| Change in 180°/sec strength knee extensor after 3 months | Change in strength knee extensor (180°/sec) at baseline and 3 months intervention | Baseline and 3 months |
| Change strength knee extensor in leg extension after 3 months | Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention | Baseline and 3 months |
| Change in sub maximal strength knee extensor in leg extension after 3 months | Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention | Baseline and 3 months |
| Change in heart rate recovery after 3 months | Change in heart rate recovery at baseline and 3 months intervention | Baseline and 3 months |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |