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The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.
3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of ~ 70% of one repetition maximal (1RM).
Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.
The investigators collect blood sample before exercice, after HIIT and after RT.
It is randomized cross-over study.
The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.
The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAD group | Experimental | Coronary artery diseases |
|
| HFrEF group | Experimental | Heart Failure with reduced Ejection Fraction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac rehabilitation with 3/7 method | Other | HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Lactate | mmol/l | within 2 minutes after TR training session on day 1 |
| change in Testosterone | nmol/l | within 2 minutes after TR training session on day 1 |
| change Glucocorticoid Cortisol | nmol/l | within 2 minutes after TR training session on day 1 |
| change in Growth Hormone | ng/ml | within 2 minutes after TR training session on day 1 |
| change in ph | venoust | within 2 minutes after TR training session on day 1 |
| change PCO2 venoust | mm Hg | within 2 minutes after TR training session on day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Borg scale | Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion) | within 4 minutes after TR training session on day 1 |
| Pleasure of the session scale | 0 = worse 10 = better |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe van de borne, Professor | Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme Hospital | Brussels | 1070 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35394146 | Background | Mang ZA, Realzola RA, Ducharme J, Bellissimo GF, Beam JR, Mermier C, de Castro Magalhaes F, Kravitz L, Amorim FT. The effect of repetition tempo on cardiovascular and metabolic stress when time under tension is matched during lower body exercise. Eur J Appl Physiol. 2022 Jun;122(6):1485-1495. doi: 10.1007/s00421-022-04941-3. Epub 2022 Apr 8. |
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on request
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|
|
| Cardiac rehabilitation with 3X9 method | Other | HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned |
|
|
| within 4 minutes after TR training session on day 1 |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000072038 | Cardiac Rehabilitation |
| ID | Term |
|---|---|
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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