This is a prospective, single-arm, non-comparative, open-label, monocular, post approval study to assess safety and device performance of the Vista Vitrectomy Probe during vitrectomy surgery.

Inclusion Criteria:

• Male or female participant with age ≥ 18 years at the time of screening.
• Subject must have a clinical indication for anterior vitrectomy.
• Subjects must be able to understand and voluntarily provide written informed consent before screening, following an explanation of the nature and purpose of this study.
• Subjects must be willing and able to comply with all treatment and follow-up study procedures.

Exclusion Criteria:

• Subjects who have experienced any significant trauma in the operative eye within the past month.
• Subjects with any active ocular infection or history of any herpetic infection that has cleared less than one month prior to the pre-operative visit.
• Subjects with prior history of uncontrolled glaucoma or uveitis refractory to treatment or ocular hypertension (IOP>30mm Hg) in study eye.
• Subjects with any medical condition (e.g., uncontrolled diabetes) that, based on the Investigator's medical judgment, poses a concern for the subjects' safety.
• Female subjects of child bearing potential with positive urine pregnancy test
• Subjects who have participated in any drug or device clinical investigation within 30 days prior to entry into or during this study.