In the REMISE is study, we will compare blood proteins, biomarkers, and other -omics prospectively collected from patients with sepsis from two sources, i.) remnant (discarded) samples from the clinical laboratory, and ii.) prospectively collected in UPMC Presbyterian hospital research coordinator specimen collected biospecimens.

Analyses will include traditional biomarkers, quantitative proteomics, metabolomics, lipidomics, transcriptomics, and pathogen genomic sequencing in both sets of samples. This data will allow the assessment of the feasibility, integrity, and scientific value of remnant samples compared to research coordinator samples collected at the bedside for mechanistic sepsis research.

Inclusion Criteria:

• Adult patient, at least 18 years of age
• Meeting Sepsis-3 criteria within 6 hours of admission
• Biospecimens obtained for routine clinical care and measurement
• Peripheral intravenous access

Exclusion Criteria:

• Patients who do not have Sepsis-3
• Traumatic injury,
• Inability to consent or contact legal representative,
• Cardiac arrest,
• Stroke,
• Comfort measures only,
• Unable to obtain intravenous access, and/or
• Subject declines to participate.
• No residual blood left in clinical sample

Adult patients with Sepsis-3 presenting to eligible emergency departments.