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This study was conducted to investigate the effects of daily supplementation of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement
This study was a 8 weeks, randomized, double-blind, placebo-controlled human trial. 40 subjects were randomly divided into Allium Cepa L. Peel Heated Water Extract or a placebo group. Immunity Enhancement profiles before and after the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Allium Cepa L. Peel Heated Water Extract | Experimental | 4 capsules/day after meal(1,200 mg/day) for 8 weeks |
|
| Placebo | Placebo Comparator | 4 capsules/day after meal(1,200 mg/day) for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allium Cepa L. Peel Heated Water Extract | Dietary Supplement | 4 capsules/day after meal(1,200 mg/day) for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Natural killer(NK) cell activity | Changes of Natural killer(NK) cell activity will be assessed before and after the intervention. PBMCs were isolated by density gradient separation, resuspended in phosphate-buffered saline, and determined using trypan blue solution. Natural killer(NK) cell activity was calculated from the results of nonradioactive cytotoxicity assay kits. Effector cells (PBMCs) were seeded in 96-well plates, with 50 ul of target cells (K562), incubated for 4 hours. cytotoxicity was calculated using the following formula: [(experimental-effector spontaneous-target spontaneous)/(target maximum-target spontaneous)]*100. | At week 0 and week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Cytokines(INF-gamma, Interleukin(IL)-2, IL-6, IL-12, Tumor Necrosis Factor(TNF)-alpha, and IL-1beta) | Changes of Cytokines(INF-gamma, IL-2, IL-6, IL-12, TNF-alpha, and IL-1beta) will be assessed before and after the intervention. the serum levels of cytokines, including INF-gamma, IL-2, IL-6, IL-12, TNF-alpha, and IL-1beta will be measured. | At week 0 and week 8 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yongsoon Park, Ph.D. | Hanyang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hanyang University | Seoul | 04763 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38352207 | Derived | Cho H, Kim S, Lee SH, Park Y. Effect of onion (Allium cepa L.) peel extract on natural killer cell and cytokines in a randomized, double-blind, placebo-controlled trial. Nutr Res Pract. 2024 Feb;18(1):33-45. doi: 10.4162/nrp.2024.18.1.33. Epub 2024 Jan 11. |
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| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| ID | Term |
|---|---|
| D007239 | Infections |
| D012140 | Respiratory Tract Diseases |
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| Placebo | Dietary Supplement | 4 capsules/day after meal(1,200 mg/day) for 8 weeks |
|
| Changes of Wisconsin Upper Respiratory Symptom Survey-21 | Changes of Wisconsin Upper Respiratory Symptom Survey-21 will be assessed before and after the intervention | At week 0 and week 4 and week 8 |