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Aortic or large arterial vessel infections are rare but serious infections. Their management is based on French and American expert opinions. The quality of evidence supporting these guidelines is low because most publications on the subject correspond to case series and few interventional studies have been performed to validate their management. However, referral centres for vascular surgery are frequently solicited to give their opinion on patients suffering from mycotic aneurysms. In addition, the last few decades have seen the improvement of vascular surgery techniques allowing the management of more and more patients, often elderly and comorbid. There has therefore been an increase in the incidence of infectious complications associated with this care. It is therefore essential to participate in research on aortic and large arterial vessel infections. For this, a monocentric cohort study seems to be an essential first step to better understand the polymorphism and complexity of these patients.
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| Measure | Description | Time Frame |
|---|---|---|
| one-year mortality | Study of all-cause mortality in patients with aortic vascular infection and large arterial vessels during the first year of follow-up after diagnosis. | one year after the diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of prognostic factors associated with arterial vascular infections | Identification of prognostic factors in patients with aortic and large arterial vessel infection: a multivariate Cox model to identify factors associated with mortality or better survival | at the time of diagnosis and up to one year afterwards |
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Inclusion Criteria:
Age ≥ 18 years
Aortic or large arterial vessel infection. The diagnosis is made on a number of criteria in favour of the diagnosis (at least 2 of the following 3 criteria):
Exclusion Criteria:
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All adults patients with proved aortic or large arterial vessel infection and without exclusion criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lefèvre Benjamin, M.D. | Contact | +33383157654 | b.lefevre@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| Lefèvre Benjamin, M.D. | Université de Lorraine & CHRU de Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Université de Lorraine, CHRU Nancy and APEMAC | Recruiting | Vandœuvre-lès-Nancy | Lorraine | 54511 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40377031 | Derived | Lalevee L, Serguei M, Jeanbert E, Simon M, Luc A, Settembre N, Henard S, Novy E, Guerci P, Lefevre B. Characteristics and outcomes of patients with infective native aortic aneurysm or vascular graft and endograft infection. Infect Dis (Lond). 2025 Oct;57(10):920-932. doi: 10.1080/23744235.2025.2502826. Epub 2025 May 16. |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| D000785 | Aneurysm, Infected |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D000783 | Aneurysm |
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| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |