Cyst is the main cause for longstanding swelling in the mandible or the maxilla, its enlargement usually results in resorption and weakening of bone. Thus the treatment of the cysts is essential to preserve the bone and the adjacent vital structures. Healing of the bone defect and its surrounding soft tissues is a critical issue that needs concerns. Although the Platelet rich fibrin has promising effects in wound healing, it can resorb during 10-14 days. Thus a new autologous platelet concentrate is introduced by Kawasi et al that can remain stable for 4-6 months called albumin PRF.

Inclusion Criteria:

• Patients suffering from jaw cystic cavity volume greater than 1cm3
• Patients with no gender predilection that agreed to present for follow-up visits for a minimum postoperative period of 6 months.
• Cystic lesion that requires removal under local or general anaesthesia.

Exclusion Criteria:

• Medically compromised patients contradicting operation.
• Patients with history of chemotherapy or radiotherapy.
• Patients with low level of platelet count.
• Patients with anticoagulant therapy.
• Patients who are unable to attend follow up appointments