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The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cancer patients | Experimental | Single exercise intervention following a HIIT protocol, duration ~20 mins |
|
| Healthy adults | Active Comparator | Single exercise intervention following a HIIT protocol, duration ~20 mins |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity interval exercise training | Behavioral | Endurance training adapted to age, resting heart rate |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Natural Killer Cells | NK cells, subgroups and innate lymphoid cells | Change from pre Intervention to immediately after intervention and 1 hour post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective Quality of Life | Quality of Life (EORTC QLQ-C30, questionnaire score from 0 - 100, higher score = better quality of life) | Once after intervention |
| Fatigue | Fatigue (EORTC QLQ FA12 Fatigue questionnaire range 0 - 100, higher score = worse outcome) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Miriam Götte, Dr. | University Hospital, Essen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Essen | Essen | North Rhine-Westphalia | 45147 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42233178 | Derived | Kiehl F, De Lazzari N, Beller R, Deppe I, Bennstein SB, Botzenhardt S, Salvador Comino MR, Tewes M, Gotte M. High-Intensity Interval Training Boosts Immune Cells in Advanced Cancer Patients and Healthy Controls: Implications for Cancer Care. Cancer Med. 2026 Jun;15(6):e71977. doi: 10.1002/cam4.71977. | |
| 40229731 | Derived |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Once after intervention |
| Nutritional status | Mini Nutritional Assessment (MNA range 0 - 14 points), lower score = worse | Once after intervention |
| Deppe I, Beller R, Kiehl F, Lazzari N, Bennstein SB, Reinhardt D, Dirksen U, Gotte M. The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled trial. BMC Cancer. 2025 Apr 14;25(1):689. doi: 10.1186/s12885-025-14058-3. |