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This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over a minimum of 4 weeks). These experiments will elucidate the relationships between LFPs oscillations, lower limb function, postural control and gait performance.
This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over a minimum of 4 weeks). These experiments will elucidate the relationships between LFPs oscillations, lower limb function, postural control and gait performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants | Inclusion criteria for all aims/experiments
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observational-- no intervention | Other | observational |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peak negative power | A servo-controlled ankle manipulandum will be used to obtain objective measures of resistance about the dorsiflexion/plantar flexion axis (range of motion approximately 5 deg. dorsiflexion to 30 deg. plantar flexion; frequency = 1.5 Hz). Two conditions will be tested: passive movement with and without an activation maneuver on the contralateral side (repetitive tapping of the toe or heel). | 30 day |
| Stride length | The spatial and temporal parameters of overground steady-state gait will be assessed in the lab or derived from the wearable device (mPower) | 30 days |
| Alpha power during standardized daily gait assessment | The participant will use their DBS device patient programmer to record a time stamp and capture LFPs using the implanted Medtronic Percept™ device during the standardized daily gait assessments. | 30 days |
| cadence | The spatial and temporal parameters of overground steady-state gait will be assessed in the lab or derived from the wearable device (mPower) | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| gait speed | The spatial and temporal parameters of steady-state gait will be assessed using a computerized walkway. | 30 days |
| time spent away from home | time spent away from home, as measured by the mPower smartphone app |
| Measure | Description | Time Frame |
|---|---|---|
| gait asymmetry | The spatial and temporal parameters of steady-state gait will be assessed using a computerized walkway. | 30 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Colum Mackinnon, PhD | Contact | 612-625-8938 | cmackinn@umn.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Recruiting | Minneapolis | Minnesota | 55414 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 30 days |
| distance traveled from home | distance traveled away from home, as measured by the mPower smartphone app | 30 days |
| alpha power immediately following freezing of gait episodes, falls and other major events | The participant will use their DBS device patent programmer to record a time stamp when they experience a freezing of gait episode and LFPs will be recorded immediately following that time by the implanted Medtronic Percept™ device | 30 days |
| Peak power of local field potential oscillations | average daytime peak alpha and beta power derived from power spectral density analysis of the local field potential signal recorded by the implanted Medtronic Percept™ device | 30 days |
| stride time variability | The spatial and temporal parameters of steady-state gait will be assessed using a computerized walkway. | 30 days |
| step length variability | The spatial and temporal parameters of steady-state gait will be assessed using a computerized walkway. | 30 days |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |