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Rationale:
Aortic diameter is currently used as a gold standard in international guidelines for prediction of aorta pathology (aortic aneurysm and aortic dissection). However, aortic diameter has proven to be insufficiently accurate for making decisions about well-timed preventive interventions. The LANDMARC study will take place in line with the FIBAA-bank ('Correlatie tussen cardiovasculaire FIBroseringsgraad en Aorta elongatie, dilatatie en Atria dilatatie (FIBAA-bank): een biobank & databank onderzoek met focus op aorta en atria' (METC-number 2022-3164)), and aims to reveal the undiscovered relationship between WSS (wall shear stress) values and aortic strain. In combination with data from the FIBAA-bank, the LANDMARC study will provide more accurate information for future risk stratification models for cardiovascular pathology (with focus on aortic disease).
Objectives:
Primary objective: indication of the association between WSS (peak WSS and WSS gradient) (through 4D-flow MR and CT) and aortic strain.
Secondary objective: indication of the association between (hemo)dynamic processes within the body (aortic elongation/aortic strain) and (patho-)physiological changes (degree of cardiovascular tissue fibrosis).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 4D-flow MR & CT-scan | Other | 4D-flow MR and CT-scan after cardiac surgery (until 12 months afterwards), for the purpose of obtaining more precise data on (hemo)dynamic processes within the cardiovascular system, in combination with data extraction from the established biobank and databank (FIBAA-bank). |
| Measure | Description | Time Frame |
|---|---|---|
| Indication of the association between WSS (peak WSS and WSS gradient) (through 4D-flow MR and CT) and aortic strain. | Previous research described the importance of aortic strain for the prediction of aortic disease. By linking this information to information that can be obtained via advanced imaging techniques, future predictions about aortic disease can be made more easily and will be more accurate. | Until 12 months postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Indication of the association between (hemo)dynamic processes within the body (aortic elongation/aortic strain) and (patho-)physiological changes (degree of cardiovascular tissue fibrosis). | During the FIBAA bank, residual tissue (e.g. aorta and atrial tissue) and blood (25ml) were collected, which were then analysed by the Biochemistry department. From these materials, data on for example elasticity and compliance was collected using different staining techniques (elastin-collagen ratio, type I-type II collagen ratio, degree of collagen fibre crosslinking, etc.). This available data is used during the LANDMARC study to indicate associations between degree of cardiovascular tissue fibrosis and aortic elongation/aortic strain. These associations will demonstrate that cardiovascular tissue response and cell interaction based on dynamic body processes and hemodynamics are important factors for the development of cardiovascular disease. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population of the LANDMARC study will consist of patients who underwent open heart surgery and have participated in FIBAA-bank.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sophie ML van de Walle, PhD student | Contact | +31643904530 | sophie.vande.walle@mumc.nl | |
| Elham Bidar, MD, PhD | Contact | elham.bidar@mumc.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MaastrichtUMC | Maastricht | Limburg | 6229 HX | Netherlands |
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| ID | Term |
|---|---|
| D001018 | Aortic Diseases |
| D001014 | Aortic Aneurysm |
| D000784 | Aortic Dissection |
| D017545 | Aortic Aneurysm, Thoracic |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000783 | Aneurysm |
| D000094665 | Dissection, Blood Vessel |
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| Until 12 months postoperative |
| D000094683 |
| Acute Aortic Syndrome |