Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.

Inclusion Criteria:

1. Elective endotracheal intubation under general anesthesia.
2. Operation time < 3 h.
3. ASA grade I or II.
4. Age 18~65 years old.

Exclusion Criteria:

1. Throat and neck surgery.
2. Those assessed to have a high risk of reflux aspiration.
3. Difficulty intubation.
4. History of snoring before surgery.
5. Recent respiratory illness such as chronic cough.
6. Previous airway hyperresponsiveness, such as asthma.
7. recent use of cough suppressants.
8. Patients with severe heart, liver and kidney diseases.