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| Name | Class |
|---|---|
| Nestlé Health Science | INDUSTRY |
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The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence. Life in a small community is very different and above all unique, which could be an asset in a research setting.
To ensure its functioning, the brain needs a lot of energy. However, during aging, it has difficulty properly using its main fuel, sugar. The brain then becomes "starved". This energy deficit is part of the vicious circle leading to memory problems. The brain, like a hybrid car, can run on two fuels, sugar and ketones. Providing alternative fuel to the brain, in the form of ketones, and thus offsetting the energy it needs, could improve its functioning and help prevent or improve memory problems.
There are several ways to increase ketones in our body such as certain dietary oils, natural health products, physical activity or certain diets. Reducing the amount of sugar in our diet is also a strategy that can increase ketones. A low-sugar diet is already widely used in the prevention of several important diseases, including type 2 diabetes and even Alzheimer's disease.
This study will assess the feasibility of a community intervention project in a seniors' residence with the eventual overall objective of slowing the progression or onset of AD and related health indicators, through a dietary modification.
This feasibility study will last 6 months. The basic characteristics of interested participants will be collected. The global spheres of evaluation are the following: metabolic profile, cognition, quality of life and nutritional status. Glucose measurements will be taken continuously via a sensor over two weeks during the project.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 days control diet | Sham Comparator | Participants stay on their regular diet while glucose is continuously monitored, heart rate and number of steps is measured for 10 days. |
|
| 10 days low carb diet | Active Comparator | Participants will eat a low carb diet while glucose is continuously monitored, heart rate and number of steps is measured for 10 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low carb diet | Dietary Supplement | low carb meals will be 50% less carbs than the regular meals |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose concentrations | in mmol/L | over 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | beats per minutes | 8 hours a day during 10 days |
| Number of steps | 8 hours a day during 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| Menu appreciation level | To measure feasibility of the study | After le 10 days of low carb diet |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rearsh Centre on Aging | Sherbrooke | Quebec | J1H4C4 | Canada |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 13, 2024 | |
| Reset | Sep 26, 2024 | |
| Release | May 28, 2025 | |
| Reset | Jun 12, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 13, 2024 | Sep 26, 2024 | |||
| May 28, 2025 |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D007662 | Ketosis |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D004032 | Diet |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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All participants will go through 10 days of control diet and 10 days of reduced carb diet.
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| Regular diet | Dietary Supplement | Regular diet |
|
|
| Jun 12, 2025 |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |