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The Balloon Analogue Risk Task [BART] is an experimental task modelizing risky behaviors. In Parkinson disease, the correlation between BART and modifications of cerebral activity in ventral striatum has been shown. BART thus seems to be particularly adapted for modelization of HYPERdopaminergic behavioral disorders [TYPER] into Parkinsonian patients. Previously, a version of the BART performed with EEG has been specifically developped by the Centre d'Investigation Clinique of Besançon University Hospital, in collaboration with the Clinical and integrative neurosciences laboratory. Preliminary data suggest that the analysis of evoked potentials including Feedback-related Negativity [FRN], P300 wave, and Reward Positivity [RewP], could help assessing the motivational and attentional attributes of decision making and the delayed treatment of any reward.
The hypothesis of the study that the EEG version of the BART could help predicting the risk to develop TYPER into Parkinsonian patients treated by dopaminergic in routine care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Experimental | Risky behaviors assessed through BART-EEG among Parkinsonian patients newly treated with dopaminergic agonists |
|
| Control | Active Comparator | Risky behaviors assessed through BART-EEG among healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BART-EEG at V1 + V2 | Behavioral | Balloon Analogue Risk Task coupled to Electroencephalogram (BART-EEG) at V1 + V2 for Parkinsonian patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under curve for dopaminergic agonist treatment | Area Under the Curve / Receiver Operating Characteristic Curve [AUC-ROC] of [FRN] amplitude measured at baseline for TYPER risk 9 months after introduction or increase of dopaminergic agonist treatment | Month 9 |
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Inclusion Criteria:
Probable Diagnosis of Parkinson's disease according to the Movement Disorder Society criteria
Parkinson disease appeared ≤ 60 years old
Disease evolving since ≥ 5 years
Daily dose for du dopaminergic treatment ≥ 200mg/day DOPA equivalent
Patients requiring in routine care the introduction or increase of dopaminergic agonists treatment because of:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthieu BEREAU, MD | Contact | 0033381668248 | mbereau@chu-besancon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Matthieu BEREAU, MD | CHU de Besançon | Principal Investigator |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| BART-EEG at V1 only | Behavioral | Balloon Analogue Risk Task coupled to Electroencephalogram (BART-EEG) at V1 only for healthy volunteers |
|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |