miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction

miRNA and FGF21 Profile in First Trimester and Efficacy of Gestational Diabetes Prediction and Pregnancy Outcomes

The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.

Participants will be retrieved blood sample during first trimester and undergone 100 gm OGTT (oral glucose challenge test) during 24-28 weeks of gestation.

Pregnant women who attended antenatal care at Maharaj Nakorn Chiang Mai hospital during first trimester were recruited.

Participants received routine standard prenatal care except,

1. additional blood test during 11-13 week 6 days (Blood was collected for further analysis)
2. performed 75gm OGTT during 24-28 week

Baseline data and pregnancy outcome were reviewed.

Inclusion Criteria:

• singleton pregnant women who attend at our clinic in first trimester

Exclusion Criteria:

• known underlying disease such as chronic hypertension, pregestational diabetes, SLE
• normal structural fetal anatomical screening
• incomplete obstetric data