Diagnostic Analysis of Oral Glucose Tolerance Test in Early Pregnancy for Gestational Diabetes Mellitus

Diagnostic Efficiency Analysis of Oral Glucose Tolerance Test and Prediction Model Establishment in the First Trimester for Gestational Diabetes Mellitus: a Prospective Cohort Study

The aim of this study is to explore the diagnostic efficacy of oral glucose tolerance test in early pregnancy and establish the prediction model for gestational diabetes mellitus, so as to provide the optimal screening of gestational diabetes mellitus in the first trimester. The treatment started when the pregnancy was confirmed by transvaginal ultrasound (around 6 weeks of gestation) and continued until 42 days postpartum. The study is a single center, prospective cohort study. A total of 781 participants within 14 weeks of gestation were recruited.

Inclusion Criteria:

• 1. Intrauterine pregnancy within 7-14 weeks of gestation
• 2. 20-45 years of age
• 3. Singleton pregnancy
• 4. Giving informed consent and willing to participate in this study
• 5. Planning to give birth in Women's Hospital School of Medicine Zhejiang University

Exclusion Criteria:

• 1. Pre-existing diabetes
• 2. Taking medications that may affect blood glucose levels within one month
• 3. Participating in other intervention studies
• 4. Recurrent abortion, threatened abortion, cervical incompetence or fetal malformation