Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue

COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue

Adhera® Fatigue Digital Program (or AFDP) is a digital health program based on behavioral and emotional change techniques that provides personalized physical and emotional self-management support for patients with long COVID-related fatigue.

The digital health solution is designed to be used for 3 months, and includes a mobile application and a smartwatch. This is a clinical study, with 30 participants in the experimental intervention group and 30 in the control group, that will be carried out at the Jordi Gol Primary Care Research Institute (IDIAPJGol) - Institut Català de la Salut and Distrito sanitario Aljarafe-Sevilla Norte (DASN) - Servicio Andaluz de Salud, in Spain. The investigators will focus on evaluating the feasibility of the program in supporting fatigue and also physical and emotional self-management and, consequently, in improving the patients' well-being and quality of life.

The COVIDAI study will collect data on symptomatology and emotional well-being in a population of patients with fatigue related to a diagnosis of long COVID for 3 months using or not using the Adhera® Fatigue Digital Program (30 participants in the experimental intervention group and 30 in the control group). The aim of the study is to evaluate the feasibility of the program in supporting physical and emotional self-management in long COVID patients with fatigue and, consequently, in improving the patients' quality of life.

Personalized digital health solutions for both physiological and psychological long COVID-related symptoms would allow an optimization of the cost-effectiveness model for the management of long COVID patients. Similarly, the early detection of complications associated to long COVID on patients from vulnerable groups would improve the care timeline and the patient's prognosis.

Inclusion Criteria:

• Individuals over 18 years of age.
• With long COVID, according to the World Health Organization (WHO) consensus definition
• Having a history of fatigue symptoms
• Obtain a score between 4 and 10 on the question "By how much do you rate your fatigue level from 0 to 10 in the last 7 days?", where 0 is no fatigue and 10 is the worst fatigue imaginable
• Have an Android or iOS smartphone compatible with the intervention program.
• Agree to participate in the study and sign the informed consent form
• Willingness and availability to comply with all study guidelines and procedures

Exclusion Criteria:

• Hospital admission during the period of study participation.
• Participation in another study with pharmacological treatment
• Patients who are not technologically literate or unable to use the mobile application.
• Known severe psychiatric illness or presence of relevant cognitive impairment, at the discretion of the recruiting physician
• With mobility restrictions that limit the patient's ability to perform mild physical activity
• Being pregnant
• Patients who do not understand or speak Catalan or Spanish.