Evaluation of the diagnostic accuracy of Mammography in the morpho-structural analysis of mammographic images in breast cancer-diagnosed patients or patients in follow-up for breast cancer by extracting a number of features describing the texture and morphology of the lesions reported in the form of a structured report explicitly developed for the study. Correlation of the data obtained from evaluating the primary endpoint with the genetic/molecular analysis on liquid biopsy.

Inclusion Criteria:

• full information on the study and signature of the informed consent
• biopsy-proven breast cancer or previous surgery for breast cancer
• willingness of the patient to undergo liquid biopsy

Exclusion Criteria:

• state of pregnancy or breastfeeding
• patients operated on for benign or inflammatory diseases

Patients are enrolled in mammography screening

The liquid biopsy will be performed on all patients who undergo a mammography examination in which a malignant focal aspect has been found and who agree to participate in the study. All patients enrolled in the study will be subjected to a peripheral venous blood sample. The ctDNA will be extracted for molecular analysis and will be performed with NGS (Next Generation Sequencing) technology.