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This study aims to investigate whether the use of nociception monitoring during general anesthesia with remimazolam-based total intravenous anesthesia has an effect on intraoperative opioid requirements and postoperative pain. This study is a randomized trial with a 50% probability of being assigned to either group. Randomization will be done by an anesthesiologist not involved in anesthesia or postoperative outcome assessment. Patients and the investigator in charge of postoperative outcomes assessment will be blinded to group allocation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ANI-guided | Active Comparator | Patients receiving remimazolam-based total intravenous general anesthesia with nociception monitoring with the ANI monitor |
|
| Standard | Experimental | Patients receiving remimazolam-based total intravenous general anesthesia based on hemodynamic variables and without ANI nociception monitoring |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analgesia Nociception Index monitor | Device | Patients will receive remimazolam-based total intravenous general anesthesia with nociception monitoring with the ANI monitor |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative remifentanil requirement | Intraoperative remifentanil requirements will be collected as primary outcome as µg/kg/min | Within the intraoperative period |
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Inclusion Criteria:
Adult patients between 19 and 64 years of age, ASA class I~III, scheduled for arthroscopic knee surgeryunder general anesthesia.
Exclusion Criteria:
Patient refusal, patients unable to read consent form, active URI or uncontrolled asthma, pneumonia, history of allergies to benzodiazepines, decreased liver or kidney function, heart failure of ejection fraction<55%, pregnant or breastfeeding patients, history of substance abuse/addiction
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| Name | Affiliation | Role |
|---|---|---|
| Seokyung Shin | Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University Health System, Severance Hospital | Seoul | South Korea |
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| Standard monitoring | Device | Patients will receive remimazolam-based total intravenous general anesthesia based on hemodynamic monitoring and without nociception monitoring |
|