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This study compares two groups of patients undergoing a gynecological surgey under general anesthesia: one group in which intraoperative analgesia is guided by the Analgesia-nociception index, and another group in which intraoperative analgesia is managed as in standard practice. The objective is to assess if the Analgesia Nociception Index may result in a decrease in total analgesic drugs consumption, a decrease in post-operative pain and in chronic pain development.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Analgesia Nociception Index | Experimental | Intraoperative remifentanil administration guided by the Analgesia Nociception Index |
|
| Usual practice | Active Comparator | Intraoperative remifentanil administration managed in standard practice |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analgesia Nociception Index | Device | : Non invasive monitor based on heart rate variability analysis, assessing the parasympathetic nervous activity |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative remifentanil consumption | total dose of remifentanil administered to the patient during general anesthesia | up to 7 hours after the beginning of general anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative morphine consumption | total dose of morphine administered to the patient to manage postoperative pain during the first 24 hours following surgery | obtained 24 hours after the end of general anesthesia |
| Persistent pain |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nada SABOURDIN, MD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'Anesthésie-réanimation chirurgicale - Hôpital Trousseau | Paris | 75012 | France |
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|
| Remifentanil | Drug | intravenous short-acting opioid routinely administered during general anesthesia |
|
phone interview asking the patient if she still feels pain related to the surgery
| : obtained one month after surgery |
| Persistent pain | phone interview asking the patient if she still feels pain related to the surgery | Obtained three months after surgery |
| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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