Analgesia-Nociception Index Guided Intraoperative Remifentanil Administration Versus Standard Practice:Evaluation of Perioperative Opioid Use

Analgesia-Nociception Index Guided Intraoperative Remifentanil Administration Versus Standard Practice : Evaluation of Perioperative Opioid Use

This study compares two groups of patients undergoing a gynecological surgey under general anesthesia: one group in which intraoperative analgesia is guided by the Analgesia-nociception index, and another group in which intraoperative analgesia is managed as in standard practice. The objective is to assess if the Analgesia Nociception Index may result in a decrease in total analgesic drugs consumption, a decrease in post-operative pain and in chronic pain development.

Inclusion Criteria:

• Elective gynecological surgery under general anesthesia
• Duration of surgery 1-7 hours
• Duration of hospital stay > 24 hours

Exclusion Criteria:

• chronic pain
• chronic analgesic medication
• neurologic disease
• psychiatric disease
• history of addiction
• kidney or liver failure
• allergy to any anesthetic or analgesic drug
• BMI > 35