Active, not recruitingObservationalLast updated Nov 28, 2025

Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI

Assessment of Immunological and Vascular Dysfunction in Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO PET and MRI

Overview

ClinicalTrials.gov ID: NCT05615415
Lead Sponsor: NYU Langone HealthOTHER
Brief Summary: The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2. The central hypothesis is that immunological and cerebrovascular dysfunction after acute SARS-CoV-2 infections mediate neuropsychiatric PASC (NP-PASC).
Study Type

Status

Overall Status: Active, not recruiting
Start Date: Feb 15, 2022Actual
Primary Completion Date: Dec 31, 2026Estimated
Completion Date: Dec 31, 2026Estimated

Study Record Dates

First Submitted: Nov 7, 2022
First Submitted that Met QC Criteria: Nov 7, 2022
First Posted: Nov 14, 2022Actual
Last Update Submitted that Met QC Criteria: Nov 26, 2025
Last Update Posted: Nov 28, 2025Actual
Last Verified: Nov 2025

NCT05656105Recruiting

Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection

NCT06920628Recruiting

PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

NCT07076862Recruiting

Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)

NCT06620406Completed

Synbiotic Therapy for NP-PASC

NCT05371522Unknown status

Neuro-inflammation and Post-infectious Fatigue in Individuals With and Without COVID-19

NCT06467773Recruiting

TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System