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In this study, the microbiota sequencing was used to investigate the changes of microbiota in the terminal ileum and the middle part of ascending colon, the mesenteric adipose tissue of ileum and ascending mesocolon, and oral cavity of patients with Crohn's disease before and after ileocecal resection, so as to further explore the role of ileocecal region in inducing remission of disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Before ileocecal resection | Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological manifestations and histological features were recruited，and the patients were admitted for right hemicolectomy | ||
| After ileocecal resection | Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological manifestations and histological features were recruited，and the patients underwent reversal of ileostoma after right hemicolectomy |
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| Measure | Description | Time Frame |
|---|---|---|
| Microbial changes of intestinal mucosa | Explore the microbial changes in the mucosa of the terminal ileum and the middle segment of the ascending colon in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis | 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Microbial changes of mesenteric adipose tissue | Explore the microbial changes in the mesenteric adipose tissue of the terminal ileum and the middle segment of the ascending colon in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis | 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Microbial changes of oral cavity | Explore the microbial changes in the buccal region of oral cavity in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis | 6 month |
Inclusion Criteria:
Clinical diagnosis of Crohn's disease
Exclusion Criteria:
Serious oral diseases (e.g. dental caries, periodontal disease) Other acute or chronic gastrointestinal diseases Probiotics or prebiotic consumption and antibiotic use within 1 month
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Crohn's patients before and after ileocecal resection were divided into two groups， the information of these individuals will be analyzed and some conclusions will be drawn.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai Xia, MM | Contact | 13588251107 | 987239945@qq.com | |
| Renyuan Gao, MD | Contact | 15601675695 | renyuangao@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 10th People's Hospital | Shanghai | Shanghai Municipality | 200072 | China |
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| D065817 | Congenital Microtia |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| D007410 | Intestinal Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |