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The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.
This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Crohn's disease group | Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological manifestations and histological features were recruited, and patients with CDAI score ≥ 150 were included in this group. | ||
| Crohn's disease remission group | Patients diagnosed with Crohn's disease after comprehensive evaluation of clinical symptoms, endoscopic features, radiological features and histological features were recruited, and patients with CDAI score < 150 were included in this group. | ||
| Healthy control group | Normal healthy people were randomly recruited as the control group |
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| Measure | Description | Time Frame |
|---|---|---|
| Oral microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls | The results were based on the 16S rRNA sequencing | 3 months |
| Small intestinal microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls | The results were based on the 16S rRNA sequencing | 3 months |
| Sputum microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls | The results were based on the 16S rRNA sequencing | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic difference of blood samples between active stage of Crohn's disease, remission of Crohn's disease and healthy controls | The metabolites of the blood samples by LC-MS will be detected | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Three different groups were created by healthy volunteers, patients with active Crohn's disease and patients with remission of Crohn's disease. The information of these individuals will be analyzed and some conclusions will be drawn.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kai Xia, MM | Contact | 13588251107 | 987239945@qq.com | |
| Renyuan Gao, MD | Contact | 15601675695 | renyuangao@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 10th People's Hospital | Shanghai | Shanghai Municipality | 200072 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35493739 | Derived | Xia K, Gao R, Wu X, Sun J, Wan J, Wu T, Fichna J, Yin L, Chen C. Characterization of Specific Signatures of the Oral Cavity, Sputum, and Ileum Microbiota in Patients With Crohn's Disease. Front Cell Infect Microbiol. 2022 Apr 13;12:864944. doi: 10.3389/fcimb.2022.864944. eCollection 2022. |
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| D007410 | Intestinal Diseases |