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This study aims to investigate effects of transcranial current stimulation (tES) and transcutaneous direct current stimulation (tsDCS) associated changes on fronto-parietal EEG and cognitive performance in patients with post stroke depression (PSD)
The investigators will perform a double blind, randomized, sham controlled, crossover study design to assess effects of tES, tsDCS and sham stimulation on the performance during a cognitive control task. The working Hypothesis is tsDCS and/or tES will enhance frontal theta oscillations as recorded on EEGs and improve task performance compared to sham stimulation.
Results from this project can potentially lead to the development of a new research tool for assessing neuromodulation strategies to treat mental disorders and their comorbidities. It will also uncover the neural correlates of cognitive deficits in PSD and provide feasible biomarkers associated with treatment response in support of a larger clinical.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcranial Electrical stimulation | Experimental | Subjects will receive transcranial electrical stimulation. |
|
| Transcutaneous direct current stimulation | Experimental | Subjects will receive Transcutaneous direct current stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Electrical stimulation | Procedure | Noninvasive electrical stimulation of lateral frontal cortex. |
|
| Measure | Description | Time Frame |
|---|---|---|
| EEG oscillations | Theta (4-8 Hz) oscillations in the mid frontal EEG | change from baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Behavior | Response time in a multi source interference task | during procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Cincinnati | Cincinnati | Ohio | 45267 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 5, 2025 | |
| Reset | Jul 23, 2025 | |
| Release | Jul 24, 2025 | |
| Reset | Aug 11, 2025 | |
| Release | Apr 30, 2026 | |
| Reset | May 29, 2026 | |
| Release | Jun 4, 2026 | |
| Reset | Jun 30, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 5, 2025 | Jul 23, 2025 | |||
| Jul 24, 2025 |
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Transcutaneous direct current stimulation | Procedure | Noninvasive electrical stimulation of the T10 spinal column. |
|
| Aug 11, 2025 |
| Apr 30, 2026 | May 29, 2026 |
| Jun 4, 2026 | Jun 30, 2026 |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |