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The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.
In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stimulation Group | Experimental |
| |
| Control Group | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulator | Device | Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation device that can excite or inhibit the brain activity depending on the stimulation protocol. It has mainly two variants including conventional c-tDCS and High-Definition HD-tDCS. |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction Time (RT) | Reaction time of the subject during a cognitive task would be a measure to assess changes in performance due to stimulation | 1 hour |
| Concentration Rate | The percentage of accurate responses during the cognitive task within the stipulated time will be calculated to see an impact on concentration after stimulation | 1 hour |
| Event related potential latency and amplitude | Changes in latency and amplitude of event related potentials including P300 & N200 would be used as neural marker to understand cognitive processing in the brain. | 1 hour |
| Functional Magnetic Resonance Imaging (fMRI) | Changes in fMRI connectivity | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Raymond Tong, PhD | Contact | +852 3943 8454 | kytong@cuhk.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Raymond Tong, PhD | Department of Biomedical Engineering, CUHK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Biomedical Engineering, The Chinese University of Hong Kong | Recruiting | Shatin | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35378119 | Derived | Khan A, Chen C, Eden CH, Yuan K, Tse CY, Lou W, Tong KY. Impact of anodal high-definition transcranial direct current stimulation of medial prefrontal cortex on stroop task performance and its electrophysiological correlates. A pilot study. Neurosci Res. 2022 Aug;181:46-54. doi: 10.1016/j.neures.2022.03.006. Epub 2022 Apr 1. | |
| 33390917 |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Khan A, Wang X, Ti CHE, Tse CY, Tong KY. Anodal Transcranial Direct Current Stimulation of Anterior Cingulate Cortex Modulates Subcortical Brain Regions Resulting in Cognitive Enhancement. Front Hum Neurosci. 2020 Dec 16;14:584136. doi: 10.3389/fnhum.2020.584136. eCollection 2020. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |