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No suitable recruitment
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| Name | Class |
|---|---|
| Beijing Tiantan Hospital | OTHER |
| Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | OTHER |
| Jiangsu Province Nanjing Brain Hospital | OTHER |
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To investigate whether a year of rasagiline may reduce the progression from idiopathic REM sleep behavior disorder (RBD) to Parkinson's disease (PD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early Intervention | Experimental | 0-52 week: rasagiline 1 mg/day |
|
| Delayed Intervention | Active Comparator | 0-26 week: palcebo 1mg/day 27-52 week: rasagiline 1mg/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rasagiline | Drug | 1 mg rasagiline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Disease-free survival time | Not diagnosed as any of the synucleinopathies (Parkinson's disease; dementia with lewy body; multiple system atrophy) | 3 years after starting rasagiline treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Striatal dopaminergic innervation | Striatal binding ratio from DAT-Scan | 0-3 years after starting rasagiline treatment |
| MDS-UPDRS-III | 0-3 years after starting rasagiline treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Baorong Zhang, MD | Second Affiliated Hospital, Zhejiang University, China | Principal Investigator |
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| ID | Term |
|---|---|
| D020187 | REM Sleep Behavior Disorder |
| D010300 | Parkinson Disease |
| D000080874 | Synucleinopathies |
| ID | Term |
|---|---|
| D020923 | REM Sleep Parasomnias |
| D020447 | Parasomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C031967 | rasagiline |
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| The First Affiliated Hospital of Anhui Medical University |
| OTHER |
| Huashan Hospital | OTHER |
| Second Affiliated Hospital of Soochow University | OTHER |
| Guizhou Medical University | OTHER |
| The First Affiliated Hospital of Guangzhou Medical University | OTHER |
| West China Hospital | OTHER |
| Sir Run Run Shaw Hospital | OTHER |
| The Affiliated Hospital of Hangzhou Normal University | OTHER |
| The First Affiliated Hospital of Dalian Medical University | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Fujian Medical University Union Hospital | OTHER |
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| MoCA | 0-3 years after starting rasagiline treatment |
| MMSE | 0-3 years after starting rasagiline treatment |
| HAMA | 0-3 years after starting rasagiline treatment |
| HAMD | 0-3 years after starting rasagiline treatment |
| RBDQ-HK | 0-3 years after starting rasagiline treatment |
| PSQI | 0-3 years after starting rasagiline treatment |
| PDQ39 | 0-3 years after starting rasagiline treatment |
| SCOPA-AUT | 0-3 years after starting rasagiline treatment |
| D001523 |
| Mental Disorders |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009069 | Movement Disorders |
| D019636 | Neurodegenerative Diseases |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |